Brain functional connectivity during induced sadness in patients with obsessive-compulsive disorder

LF Fontenelle; BJ Harrison; J Pujol; CG Davey; A Fornito; E Bora; C Pantelis; M Yücel

Journal article

Brain functional connectivity during induced sadness in patients with obsessive-compulsive disorder

LF Fontenelle, BJ Harrison, J Pujol, CG Davey, A Fornito, E Bora, C Pantelis, M Yücel

Journal of Psychiatry and Neuroscience | CMA-CANADIAN MEDICAL ASSOC | Published : 2012

DOI: 10.1503/jpn.110074

Abstract

Background: Obsessive-compulsive disorder (OCD) is associated with a range of emotional abnormalities linked to its defining symptoms, comorbid illnesses and cognitive deficits. The aim of this preliminary study was to examine functional changes in the brain that are associated with experimentally induced sad mood in patients with OCD compared with healthy controls in a frontolimbic circuit relevant to both OCD and mood regulation. Methods: Participants underwent a validated sad mood induction procedure during functional magnetic resonance imaging. Analyses focused on mapping changes in the functional connectivity of the subgenual anterior cingulate cortex (ACC) within and between the 2 grou..

View full abstract

University of Melbourne Researchers

Ben Harrison Author

Chris Davey Author

Christos Pantelis Author

Related Projects (6)

EMERGING MENTAL DISORDERS IN YOUNG PEOPLE: USING CLINICAL STAGING FOR PREDICTION, PREVENTION AND EARLY INTERVENTION

Mental disorders are a major cause of disability in Australia, especially for young people. We have developed a clinical staging model cover..

RESEARCH FELLOWSHIP - PROF CHRISTOS PANTELIS

I have established and head the Melbourne Neuropsychiatry Centre within the University of Melbourne. My university position is a research ch..

Specific Brain Networks Related to the Symptoms of Obsessive-Compulsive Disorder

EMERGING MENTAL DISORDERS IN YOUNG PEOPLE: USING CLINICAL STAGING FOR PREDICTION, PREVENTION AND EARLY INTERVENTION

Mental disorders are a major cause of disability in Australia, especially for young people. We have developed a clinical staging model cover..

The self and social engagement in young people with depression and at high risk of depression.

EMERGING SEVERE MENTAL ILLNESS IN YOUNG PEOPLE

Mental disorders, such as psychotic and severe mood disorders, are the largest cause of disability in Australia. However, there is still lit..

Grants

Awarded by National Health and Medical Research Council

Funding Acknowledgements

None declared for J. Pujol and E. Bora. L. F. Fontenelle declares having received grant funding from the Department of Education, Employment, and Workplace Relations, government of Australia (Endeavour Research Fellowship Award #1415_2010) and the Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (Bolsa de Produtividade em Pesquisa #303846/2008-9). B. J. Harrison is supported by a National Health and Medical Research Council of Australia (NHMRC) Clinical Career Development Award (ID 628509). C. G. Davey is supported by an NHMRC Training (postdoctoral) Fellowship (ID 628922). A. Fornito is supported by an NHMRC CJ Martin Fellowship (ID 454797). C. Pantelis is supported by an NHMRC Senior Principal Research Fellowship (ID 628386) and NHMRC program grants (ID 350241, 566529). M. Yucel is supported by an NHMRC Fellowship Award (ID 1001973). This research was supported by an NHMRC project grant (ID 236175).